RECOMBINANT
PROTEINS

Arterra has many years of expertise in the expression of recombinant proteins in numerous cell systems: bacteria, yeasts, insect cells, mammalian cells and plant cells. We develop in vitro plants and cell cultures that stably express heterologous proteins while we carry out the transient expression of the most important plants used in molecular farming via agro-infiltration.

Using recombined DNA methodologies, we can both modify the metabolic pathway of plants by favouring the accumulation of metabolites of nutritional interest and over-express heterologous proteins. We have recently produced enzyme-enriched tomato cells derived from extremophilic bacteria. These “extremezymes” expressed in plant cells preserve important technological characteristics of the original organisms such as stability at high temperatures, salinity or radiation exposure.

Thanks to the systems available for the expression of recombinant proteins, we can carry out the screening of compounds to be used for the treatment of the inflammatory state and the various related diseases. Plant cells enriched with antioxidant enzymes, resistant to high doses of UV and ionizing radiation, have great potential as a device to prevent oxidative stress in cells subjected to treatments with ionizing radiation.

Recombinant proteins such as antibodies, hormones and antigenic molecules potentially capable to prevent and to treat pathological processes can be produced in the various systems available at Arterra.